Can Cannabidiol Help Prevent and Treat Gastrointestinal Disorders? Insights from Experts

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Numerous people look for a “cannabis store near me” to obtain marijuana for either medicinal purposes or recreational enjoyment. It is widely recognized that cannabis products may help alleviate symptoms such as anxiety, depression, pain, nausea, and vomiting. Have you ever contemplated its impact on gastrointestinal disorders?

Key Takeaways:

• Cannabinoids within the plant interact with the endocannabinoid system in the digestive tract.
• Cannabis and pain relief medications can assist in managing Irritable Bowel Syndrome symptoms.
• cannabis serves multiple purposes, but it is primarily acknowledged for its recreational and medicinal uses.

Gastrointestinal Disorders and the cannabis Plant

The influence of nutraceuticals on gastrointestinal (GI) wellness is widely recognized. Certain dietary patterns have the potential to prevent or alleviate various GI issues. Researchers have identified and evaluated the food components responsible for these effects.

Cannabis-derived nutraceuticals are among those that could be beneficial for treating GI disorders. cannabis refers to products sourced from the cannabis Sativa plant, a fragrant annual flowering herb.

In a scientific review, John M. McPartland noted that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. The cannabis genus, sativa, includes three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, cannabis sativa can serve various functions, including fiber production, oil extraction from seeds, and primarily recreational or medicinal uses.

The Impact of the Plant

Receptors and ligands of the endocannabinoid system are present throughout different areas and systems, both within and outside the GI tract, relevant to managing GI functions. The presence of cannabinoid receptors allows cannabinoids, including non-psychoactive phytocannabinoids, to modulate GI functions across health and disease states. The endocannabinoid system plays a role in regulating motility, secretion, epithelial barrier function, and viscerosensitivity.

Irritable Bowel Syndrome (IBS)

IBS has various contributing factors, affecting 10–20% of individuals in developed countries. It presents as functional gastrointestinal disturbances with no identifiable organic causes.

The enhancement of the antinociceptive properties of cannabinoids amid inflammation highlights the importance of the endocannabinoid system in visceral hypersensitivity. This insight not only clarifies the mechanisms behind conditions like IBS and other GI disorders but also suggests promising therapeutic possibilities for relieving abdominal and visceral pain.

Cannabinoids alone may not provide substantial relief in reducing visceral hypersensitivity among IBS patients. Investigating combinations with other pain-modulating agents, including opioids, presents an intriguing alternative worth exploring.

Inflammatory Bowel Disease (IBD)

IBD, such as Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition affecting the GI tract. These diseases arise from environmental, genetic, and epigenetic influences.

Cannabidiol exhibits significant anti-inflammatory properties across various models of intestinal inflammation in animal studies, as indicated in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD showed a dose-dependent improvement in disease indicators:

• Reduction of structural damage
• Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.

A study from the Inflammatory Diseases Journal indicated that their primary finding was the challenging tolerability of the botanical extract, with 90% of participants reporting treatment-related adverse effects compared to 48% receiving the placebo. A trend toward improved quality of life scores and a positive shift in patients’ overall impressions of change was observed. The authors speculate that the CBD-rich botanical extract might offer therapeutic benefits to those who can tolerate its effects.

Gastrointestinal Cancer

GI cancers, including colorectal cancer (CRC), are among the most frequently diagnosed conditions in the general population.

Numerous studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, elevate endocannabinoid levels, and inhibit the proliferation of colorectal cancer cells in vitro.

Confirmation of CBD’s chemopreventive properties was achieved through studies focusing on AOM-induced colon cancer. CBD at a dosage of 1 mg/kg resulted in a significant reduction: ACF decreased by 67%, while the number of tumors and polyps fell by 66% and 57%, respectively. An increase to 5 mg/kg showed efficacy primarily in preventing polyp formation.

THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.

Nausea and Vomiting

Positive outcomes of CBD are evident when combined with THC, as highlighted in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic effects may result from the indirect stimulation of somatodendritic 5-HT1A receptors in the dorsal raphe nucleus, potentially leading to reduced release of 5-HT in specific forebrain regions.

Gastroesophageal Reflux Disease (GERD)

Cannabinoids inhibit transient LES relaxations through a CB1-dependent mechanism in both dogs and ferrets, according to a study from the Journal of Cannabis and Cannabinoid Research. This is significant, as transient LES relaxations are the primary mechanism underlying gastroesophageal reflux disease.

cannabis for GI Issues

Conclusion

Numerous studies suggest that the benefits of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive molecules like CBD, which have been less thoroughly examined. The cannabis plant affects the GI system by interacting with the endocannabinoid system to activate multiple functions that can aid in managing symptoms of specific GI conditions.

Frequently Asked Questions

What can you expect when buying from online cannabis stores?

1. Accessing your cannabis products in Canada from an online store opens up numerous options featuring both timeless favorites and new products.
2. You can expect additional advantages such as special offers, secure payment options, and shipping methods covering most provinces.
3. Essential resources, like a blog or contact page, are available to provide customers with insights or assistance during their shopping experience.
4. As part of the purchase process, you’ll need to confirm your age by presenting identification.
5. Some stores include taxes in their product prices, while others calculate it at checkout.
6. Some dispensaries accept online payments like Interac E-Transfer, while others allow cash on delivery.

What is the measurement unit when buying from a cannabis website?

There are two primary forms of measurement: metric and imperial units. On a cannabis site, you’ll encounter measurements in grams or ounces, enabling you to find products like 3.5 grams or 1/8 ounces.

What distinguishes cannabis for medical use from that used recreationally?

Medical cannabis and recreational cannabis come from the same plant species, yet their different effects and intended uses distinguish them. Medical cannabis acts as a therapeutic aid for specific health issues, generally containing a higher CBD concentration than its recreational counterpart.

Are there ready-made joints available in a cannabis store?

Yes. These are offered as pre-rolls. cannabis pre-rolls, or pre-rolled joints and blunts, are convenient options for those who prefer their cannabis ready for use. There is a growing trend in the popularity of pre-rolled joints infused with cannabis concentrates.

Do cannabis online stores have a physical shop?

Not all online stores operate physical locations, allowing you to have your purchases delivered directly to your home rather than needing to pick them up from a physical store after placing an order online.

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